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Islet Cell Antibodies (ICA), Serum

Includes 1 test
10 Days

Antibody test against pancreatic islet cells is used in the differential diagnosis of type 1 diabetes by type 2 diabetes, in identifying individuals at risk for type 1 diabetes (including relatives of patients with diabetes) and in predicting the need for treatment with insulin in patients with adult-onset diabetes.

Autoantibodies to pancreatic islet cells are known to be associated with type 1 diabetes mellitus. In recent years, several autoantigens have been identified against which islet cells antibodies are directed. These include islet antigen 2 (IA2) associated with tyrosine phosphatase, glutamic acid decarboxylase 65 (GAD65), the zinc transporter ZnT8, and insulin. One or more of these autoantibodies are detected in 96% of patients with type 1 diabetes and are detectable before the onset of clinical symptoms, as well as in symptomatic individuals.

IA2 antibodies have a sensitivity of 57% and a specificity of 99% for the laboratory diagnosis of type 1 diabetes. Autoantibodies in patients who are going to develop type 1 diabetes are usually detectable before the age of 3 years. Some patients with type 1 diabetes are initially diagnosed with type 2 diabetes because of the onset of symptoms in adulthood, obesity, and early insulin independence. These patients with latent autoimmune diabetes can be distinguished from patients with type 2 diabetes by the detection of one or more autoantibodies to pancreatic islets (including IA-2).



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Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

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Tests includedIncludes 1 test
Sample Blood
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