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Interleukin 5 (IL-5)

Includes 1 test
2 Days

Interleukin 5 (IL-5) has also been described as B-cell growth factor II due to induction to proliferation and secretion of immunoglobulins by activated B cells. It belongs to the group of cytokines that include IL-3, IL-5, and GM-CSF. Many other activities have also been attributed to this cytokine, including the development and differentiation of eosinophils from bone marrow stem cells, induction of IL-2R membrane receptor expression in activated B cells, and increased IgA secretion by LPS-stimulated B-cells. IL-5 is produced by the Th2 subpopulation of helper T-cells, while smaller amounts are secreted by activated eosinophils and mast cells. The range of biological activities of IL-5 in B cells as well as other cell types suggests that IL-5 plays an important functional role in the activities of Th2 cells. IL-5 is a highly glycosylated glycoprotein with a molecular weight of 45 to 60 kDa.

In humans, IL-5 primarily affects eosinophilic cells and promotes their differentiation, maturation, activation, migration, and survival. Although eosinophilic lung infiltration is a feature of allergic asthma that may be due to IL-5, the therapeutic administration of anti-IL-5 antibodies did not appear to alter the symptoms of asthma in clinical trials. Administration of anti-IL-5 antibodies can, however, reduce circulating eosinophils by 50% and has shown good efficacy in the treatment of the hypereosinophilic syndrome. IL-5 has also been reported to be a differentiating factor for basophils and may promote basophils to secrete histamine and leukotrienes.



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Tests includedIncludes 1 test
Sample Blood
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