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Cortisol Free, Urine

Includes 1 test
1 Day

Free cortisol measurement in urine is performed as a screening test for Cushing's syndrome.

More Information

The diagnosis of Cushing syndrome (CS) requires evidence of cortisol hypersecretion. While serum cortisol levels fluctuate unpredictably and are strongly dependent on concurrent cortisol-binding globulin (CBG) levels, a 24-hour urine specimen integrates the cortisol production for an entire day and is not affected by CBG. Urinary cortisol reflects the portion of serum-free cortisol filtered by the kidney and correlates well with the cortisol secretion rate.

The most common causes of Cushing syndrome are pituitary adenoma (65% to 70%), adrenal tumor (15% to 20%), and ectopic Cushing (10% to 15%).

Measurement of free cortisol in urine is not useful in the evaluation of adrenal insufficiency because results overlap with normal ranges. Increased excretion may be found with the pseudo-Cushing syndrome, trauma, infection, pregnancy, and oral contraceptives.

Additional information
Tests includedIncludes 1 test
Sample Urine
Procedure completion test
Step 1

Book an appointment and buy the test online

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Step 2


Visit the certified laboratory of Diagnostiki Athinon on the date and time you have chosen, to perform the sampling.

Step 3

Receiving the test results

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