Determination of alkaline phosphatase isoenzymes is used to diagnose and monitor the treatment of diseases of the liver, bone, intestine, and parathyroid glands, to determine the cause of elevated serum alkaline phosphatase, and to differentiate between hepatic or bone causes.
Alkaline phosphatase (ALP) is found in various tissues, including the liver, bone, intestine, and placenta. Serum alkaline phosphatase activity is derived from all isoenzymes from these tissues. Serum alkaline phosphatase measurement is used for the differential diagnosis of two groups of pathologies: hepatobiliary and bone diseases with elevated osteoblastic activity.
Increased ALP activity occurs in all forms of cholestasis, especially in obstructive jaundice. The liver's response to any form of biliary obstruction is to synthesize more alkaline phosphatase than the adjacent bile duct.
ALP also increases in skeletal system disorders that have increased osteoblast activity and remodeling, such as Paget's disease, osteomalacia, fractures, and malignant bone tumors.
Moderate increases in alkaline phosphatase can also be observed in other pathological disorders such as Hodgkin's disease, congestive heart failure, ulcerative colitis, peripheral enteritis, and intra-abdominal bacterial infections.
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
