URL path: Index page // Gamma-Aminobutyric Acid (GABA), Stool

Gamma-Aminobutyric Acid (GABA), Stool

Includes 1 test
Faeces
5 Days
45€

Gamma-aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the central nervous system (CNS). It is biosynthesized by glutamate decarboxylase, which catalyzes the alpha-decarboxylation of glutamate to GABA and CO2. Glutamate is an excitatory neurotransmitter in the CNS. Hence, balance between these neurotransmitters is crucial to maintaining a stable nervous condition. GABA production has been reported in several species of gut microbiome belonging to the families Bifidobacteriaceae, Lactobacillaceae, Bacteroidaceae, Enterococcaceae, Propionibacteriaceae, and Streptococcaceae. Bifidobacterium can produce GABA from specific strains of B. dentium, B. angulatum, B. adolescentis, and B. longum subsp. infantis.

GABA-producing bacteria are considered glutamate consumers as glutamate activates enzymatic conversion using microbial glutamate decarboxylases. Microbial GABA can pass from the gut to other organs through several pathways, including the blood or vagal pathways. It has been reported that mental disorders, such as depression, are negatively correlated with the abundance of GABA-producing Bacteroides. Further, accumulating evidence suggests that the ingestion of GABA-producing bacteria (probiotics) supports relief from psychiatric illnesses, such as depression, and physical ailments, such as diabetes.

Understanding the relationship between microbial composition and the level of fecal neurotransmitters can highlight the vital role of some microbes, redirecting the microbiome's activity toward GABA production.

Recent studies support the critical role of GABA in irritable bowel syndrome (IBS). High GABA concentrations relieve abdominal pain, while low GABA concentrations are associated with increased abdominal tenderness and pain in patients with IBS. In these cases, the action of GABA is achieved through local receptors in the intestine and by action in the CNS through the gut-brain axis.

Procedure completion test
Step 1

Purchase the test you want online

Select the tests you wish, through the most complete range of Preventive and Functional Medicine tests and purchase them online.

Step 2

Sampling

We send you the certified package - sampling collection kit, to collect your sample, always in accordance with the instructions contained within the kit.

Step 3

Sending your sample

After you have collected your sample, place it in the prepaid shipping package, contact the courier company and send it to our certified laboratory.

Step 4

Receiving the test results

Download your test results easily and securely anytime you want by logging in to your personal account.

Step 1

Book an appointment and buy the test online

Select from the most complete range test of Prevention, Andrology and Diagnostics, book an appointment in real time and purchase them online.

Step 2

Sampling

Visit the certified laboratory of Diagnostiki Athinon on the date and time you have chosen, to perform the sampling.

Step 3

Receiving the test results

Download your test results easily and securely anytime you want by logging in to your personal account.

Share it