Testing for fructose in semen is used in the investigation of male infertility, particularly in patients with azoospermia and hypospermia (low sperm volume), as well as in testing the function of the seminal vesicles.
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Poor semen quality can result from either the production of abnormal spermatozoa by the testes, damage to the spermatozoa during their journey from the testes to the epididymis, or abnormal secretions from the accessory glands of the genital tract. Secretions from the accessory glands can be measured to assess the function of the specific glands, e.g., citric acid, zinc, and acid phosphatase for the prostate, fructose and prostaglandins for the seminal vesicles, L-carnitine, and neutral α-glucosidase for the epididymis.
Urogenital tract infections can sometimes decrease the secretion of these markers, but the overall measured value may remain within the normal range. An infection can also cause irreversible damage to the secretory epithelium, reducing the secretory capacity even after treatment.
The measurement of fructose in semen reflects the secretory function of the seminal vesicles. Under the influence of testosterone, the seminal vesicles produce fructose, which provides energy to the sperm for metabolism and movement.
A semen sample that has no sperm (azoospermia) and is also negative for fructose may indicate the absence of the seminal vesicles or the absence of the vas deferens in the area of the seminal vesicles or the presence of an obstruction at the level of the seminal vesicles.
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
