Vitamin K1 measurement is used in the investigation of hypovitaminosis and toxic hypervitaminosis and to monitor supplement therapy.
Vitamin K1 (phylloquinone) is a fat-soluble vitamin and is found in high amounts in leafy green vegetables and some fruits (avocado, kiwi). It is a cofactor that is involved in the glutamic acid carboxylation of many proteins. In particular, the inactive forms of the coagulation factors prothrombin (factor II), factors VII, IX, and X, protein S and protein C are converted to their active forms by carboxylation of glutamic acid to gamma-carboxyglutamic acid.
Certain other proteins, such as those involved in bone metabolism, cell growth, and apoptosis (cell death) are also subjected to this transformation of glutamic acid carboxylation.
The deficiency of vitamin K1 results in reduced concentrations of circulating, active coagulation factors, which can often lead to bleeding. Interest in vitamin K1 has increased beyond its established function in blood coagulation, with epidemiological studies suggesting that vitamin K1 may reduce bone loss in osteoporotic individuals and the risk of fractures.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
