Vancomycin measurement is used to monitor drug levels in the body during treatment.
Vancomycin is an antibiotic that inhibits the cell wall synthesis of Gram-positive microbes. It is very often used in the treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and in the treatment of pseudomembranous colitis.
Vancomycin is metabolized in the liver and is excreted mainly by the kidneys and a small amount is excreted by the bile. Oral vancomycin is mainly excreted in feces. The half-life of vancomycin is highly dependent on renal function. Rapid administration of vancomycin has been associated with the release of histamine which causes redness and itching in the skin.
At toxic levels, vancomycin can cause hypotension, leukopenia, neutropenia, exfoliating dermatitis, dacryorrhea, thrombocytopenia, dermatitis, tubular necrosis, deafness, colitis, ototoxicity (levels > 30 μg/mL for a sufficient time).
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
