Thyroglobulin (Tg) is a thyroid glycoprotein that plays a role in the synthesis of triiodothyronine (T3) and thyroxine (T4). Thyroglobulin is produced by normal thyroid cells and by papillary and follicular thyroid cancer cells. Thyroglobulin measurement is used to evaluate the efficacy of thyroid cancer treatment and to monitor for possible recurrence of the tumor when the entire thyroid gland has been removed. Thyroglobulin evaluation can also be used when there are symptoms of hyperthyroidism or when the thyroid gland is swollen.
Measurement of thyroglobulin in patients with differentiated thyroid cancer should be avoided during pregnancy as it increases during normal pregnancy and returns to its original levels after childbirth.
Possible Interpretations of Pathological Values
- Increase: Goiter, Graves' disease, liver failure, metastatic thyroid carcinoma, pregnancy. Medications: Levothyroxine.
- Decrease: Thyroid agenesis, thyroidectomy.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
