Screening for SS-A and SS-B antibodies is used to evaluate patients with signs and symptoms of connective tissue disease and in particular signs and symptoms compatible with Sjogren's syndrome or lupus erythematosus and in whom screening for antinuclear antibodies (ANA) are positive.
The SS-A (Ro) and SS-B (La) antibodies are autoantibodies formed against ribonucleoprotein molecules. These antibodies are more common in Sjogren's syndrome, a disorder with symptoms similar to those of connective tissue disorders such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and scleroderma. The syndrome is characterized by reduced secretion and eventually destruction of the exocrine glands, resulting in mucosal and conjunctival dryness.
These tests are used in the differential diagnosis of Sjogren's syndrome, SLE, and mixed connective tissue disease.
What Do Pathological Values Mean?
- Increase: seronegative lupus, neonatal lupus, scleroderma, Sjogren syndrome
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
