The measurement of serotonin in the urine is mainly used to diagnose certain cancerous tumors and to monitor their treatment.
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Serotonin, or 5-hydroxytryptamine, is an indolamine synthesized from L-tryptophan, a basic amino acid from intestinal mucosa cells. Serotonin is stored in platelets but is also found in many tissues of the body, including the central nervous system and the gastrointestinal tract. Serotonin mediates cardiovascular integrity, neurotransmission, contraction of smooth muscle fibers (gastrointestinal motility), prolactin and growth hormone release, and blood clotting functions. This wide range of actions occurs as a result of the presence of serotonin receptors throughout the body.
Serotonin measurement is most commonly used to confirm the diagnosis of cancerous tumors.
Possible Interpretations of Pathological Values
- Increase: Carcinogenic syndrome, cystic fibrosis, Duchenne muscular dystrophy, endocarditis, idiopathic hypertension, Huntington's disease, metastases, migraine, myocardial infarction, celiac disease, lung, lung cancer, lung cancer inducing ectopic production, primary pulmonary hypertension, schizophrenia, myeloid thyroid cancer (causing ectopic production). Medications: Imipramine, methyldopa, monoamine oxidase inhibitors (MAOIs), reserpine, selective serotonin reuptake inhibitors (SSRIs) (citalopram, desmethylsitaloprami, Fluoxetine, Milnacipran, norfluoxetine, paroxetine, sertraline, venlafaxine), tramadol (reduced reuptake of serotonin)
- Decrease: Depression, Down Syndrome, Parkinson's Disease, Phenylketonuria, Renal Failure, Tumors (Benign Cysts)
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
