URL path: Index page // Proinsulin


Includes 1 test
14 Days

The measurement of proinsulin in serum provides useful information for the diagnosis of insulinomas. Proinsulin levels have also been shown to be elevated in non-insulin-dependent diabetics (NIDDM), in insulin-dependent diabetics (IDDM), and in other clinical situations.

More Information

Proinsulin is the precursor of insulin, which is the principal hormone responsible for the control of glucose metabolism. Proinsulin (PI), a polypeptide of 9390 MW (86 amino acids) is synthesized in the β cells of the Islets of Langerhans in the pancreas. This protein is processed into C-peptide and insulin forms. Both are secreted in equimolar amounts into the blood. Only 1% to 3% of proinsulin is secreted intact. However, because proinsulin has a longer half-life than insulin, circulating proinsulin concentrations are in the range of 5% to 30% of circulating insulin concentrations on a molar basis, with the higher relative proportions seen after meals and in patients with insulin resistance or early type 2 diabetes. Proinsulin can bind to the insulin receptor and exhibits 5% to 10% of the metabolic activity of insulin.

The level of proinsulin in serum can reflect beta cell status and a consequence of dysfunction of proinsulin processing and/or secretion. Proinsulin is increased in clinical conditions such as insulinoma, familial hyperinsulinemia, and non-insulin-dependent diabetes mellitus.

Proinsulin levels might be elevated in patients with insulin-producing islet cell tumors (insulinomas). These patients suffer from hypoglycemic attacks due to inappropriate secretion of insulin by the tumors. The inappropriate over-secretion of insulin by insulinomas causes the release of an increased number of secretory granules with incompletely processed insulin, resulting in elevated serum proinsulin concentrations

Additional information
Tests includedIncludes 1 test
Sample Blood
Procedure completion test
Step 1

Book an appointment and buy the test online

Select from the most complete range test of Prevention, Andrology and Diagnostics, book an appointment in real time and purchase them online.

Step 2


Visit the certified laboratory of Diagnostiki Athinon on the date and time you have chosen, to perform the sampling.

Step 3

Receiving the test results

Download your test results easily and securely anytime you want by logging in to your personal account.

Share it