The measurement of phenobarbital in serum is used to monitor drug levels in the body during treatment, to check patient compliance with treatment, and to assess any toxicity from the drug.
More information
Phenobarbital (Luminal, Gardenal, Kaneuron, Lumidrops) is a long-acting barbiturate drug most commonly used for its anticonvulsant (antiepileptic) effects and occasionally as a sedative. It is distributed throughout the body and metabolized by the liver, with 50% excreted unchanged in the urine. Its half-life is usually 50-120 hours in adults and 40-70 hours in children.
The test is used in suspected drug toxicity or abuse by patients with symptoms such as lethargy, dizziness, ataxia, and diplopia. It is also used to monitor therapeutic levels of phenobarbital, especially in seizure disorders during adolescence, after weight loss or gain, and when patients develop renal failure.
Possible Interpretations of Pathological Values
- Increase: Drug abuse (barbiturates), renal failure in patients receiving phenobarbital therapy. Medications that may increase levels in patients receiving phenobarbital: Monoamine oxidase inhibitors (MAOIs), sodium valproate, valproic acid
- Decrease: (Below therapeutic range) Inadequate treatment, patient non-compliance, malabsorption (oral doses)
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
