Serum paracetamol is used to assess any drug toxicity in cases of overdose.
More information
Paracetamol or otherwise acetaminophen (Depon) is used as a painkiller and anti-fever medication without significant anti-inflammatory effects, which can become hepatotoxic when taken at concentrations greater than 150 mg/kg.
The liver metabolizes it with a normal half-life of less than 4 hours. At overdose, liver glutathione is consumed, and the toxic metabolite produced reacts with the cellular proteins, resulting in hepatotoxicity, potentially lethal if left untreated. N-acetylcysteine can substitute for glutathione and serves as an antidote.
Serum paracetamol concentration and knowledge of half-life is the only way to assess early-onset poisoning, as other liver function tests (bilirubin, transaminases) do not show clinically significant increases until they develop in the liver.
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
