Measuring the osmotic resistance of red blood cells is used to screen for hereditary spherocytosis and confirm and investigate mild spherocytosis.
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Spherocytes (i.e., spherically shaped red blood cells) are osmotically fragile and rupture more quickly in a hypotonic solution than normal red blood cells. Because they have a smaller surface area to volume ratio, they are more easily lysed than normal discoid red blood cells. Cells with a larger surface area to volume ratio, such as target cells and hypochromic red blood cells, are more resistant to lysis.
Patients with G-6-PD, pyruvate kinase deficiency, or other red blood cell disorders may test positive.
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
