The mono-test is performed to diagnose infectious mononucleosis rapidly.
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Infectious mononucleosis is a viral disease that affects the reticuloendothelial system. It is generally limited to children and young adults and is usually caused by the Epstein-Barr virus (EBV). The disease is characterized by fever, sore throat, lymphadenopathy, headache, and fatigue; based on symptoms alone, it can be confused with other diseases. The presence of heterophile antibodies also characterizes ιnfectious mononucleosis.
The mono-test (mononuclear test) quickly detects heterophilic antibodies (adhesins). A positive mono-test result, combined with concomitant clinical and/or hematologic findings, confirms the diagnosis of infectious mononucleosis. Approximately 10% of patients with infectious mononucleosis have negative heterophilic antibodies. In these cases, specific antibodies against Epstein-Barr-specific viral antigens may be present.
Heterophile antibodies may appear in the serum approximately 6-10 days after exposure. Their presence may persist for up to 1 year, with their concentration peaking between 4 and 8 weeks after the onset of infection.
Possible Interpretations of Pathological Values
- Increase: Adenovirus, Burkitt lymphoma, cytomegalovirus, Epstein-Barr virus, herpes simplex virus, HIV, Hodgkin's disease, infectious mononucleosis, Izumi fever, leukemia, malaria, pancreatic cancer, rubella virus, rheumatoid arthritis, sarcoidosis, serum sickness, systemic lupus erythematosus, viral or infectious hepatitis
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
