Determination of anti-mitochondrial antibodies is used in the diagnosis of primary biliary cirrhosis.
Anti-mitochondrial antibodies (AMA) are autoantibodies formed against a lipoprotein component of the mitochondrial membrane. These antibodies tend to attach to organs that consume a lot of energy, such as those of the hepatobiliary system. Anti-mitochondrial antibodies are present in 90% of patients with primary biliary cirrhosis and less frequently in patients with other autoimmune diseases.
To confirm primary biliary cirrhosis, M2 anti-mitochondrial antibodies should be tested.
What Do Pathological Values Mean?
- Increase: Cryptogenic cirrhosis, drug-induced jaundice, hepatic obstruction, hepatitis, primary biliary cirrhosis, rheumatoid arthritis, systemic lupus erythematosus.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
