Measurement of thyroid peroxidase antibodies (anti-microsomal antibodies) is used for laboratory diagnosis and confirmation of autoimmune thyroid diseases and their differential diagnosis of non-autoimmune thyroid diseases.
Microsomes (or otherwise thyroid peroxidase, TPO) are lipoproteins that are normally found in the thyroid epithelial cells. In certain types of thyroid disorders, microsomes escape their normal positions. Once released, they appear in the bloodstream as antigens in the body, resulting in the immune system producing antibodies against the microsomes, thereby leading to inflammation and destruction of the thyroid gland. Anti-microsomal antibodies are found in the majority of patients with Hashimoto's thyroiditis. Anti-microsomal antibodies are usually measured in combination with anti-thyroglobulin (anti-TG) antibody test.
What Do Pathological Values Mean?
- Increase: Autoimmune hemolytic anemia, granulomatous thyroiditis, Hashimoto's thyroiditis, juvenile lymphocytic thyroiditis, myasthenia gravis, myxedema, nodular goiter, pernicious anemia, primary hypothyroidism, rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, thyroid cancer. Medications: oral contraceptives.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
