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Lipoprotein A (Lp(a)), A5673G Mutation

Includes 1 test
Blood, Other
5 Days

Molecular testing for the A5673G mutation of the lipoprotein alpha [Lp(a)] gene is performed to assess the risk of thrombosis in asymptomatic patients with a severe family history or in patients who have already experienced a thromboembolic episode.

Polymorphisms in the lipoprotein alpha [Lp(a)] gene appear to predispose to coronary heart disease, vascular stroke, early atherosclerosis, thrombosis, and stroke. The existence of the A5673G mutation, either in heterozygotes or in homozygotes, is associated with elevated levels of lipoprotein alpha. Individuals with the above polymorphism have a 2-fold increased risk of developing cardiovascular disease but appear to benefit from aspirin administration.

Thrombophilia is an acquired or congenital disorder associated with thrombosis. The clinical appearance of an underlying thrombophilia mainly involves venous thromboembolism, which is manifested as deep vein thrombosis, pulmonary embolism, or superficial vein thrombosis. Other events associated with thrombophilia include recurrent pregnancy loss and complications of pregnancy such as severe preeclampsia, placental abruption, and intrauterine fetal demise. The demographic and environmental characteristics that contribute to the risk of venous thromboembolism in people predisposed to thrombophilia include old age, gender (more commonly in men), obesity, surgery, trauma, hospitalization for other diseases, malignant neoplasms, prolonged immobility (such as long air travel), use of certain medications (such as contraceptives, estrogens, tamoxifen, raloxifene, and certain drugs used for the treatment of infertility).



Important Note

Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.

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Additional information
Tests includedIncludes 1 test
Sample Blood, Other
Procedure completion test
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