Serum levetiracetam is used to monitor drug levels in the body during treatment, to monitor patient compliance with treatment, and to evaluate any drug toxicity.
Levetiracetam (Keppra) is used in the treatment of myoclonic and tonic-clonic seizures and also (except where appropriate) in manic conditions and in migraine prevention. Levetiracetam has good bioavailability and rapid attainment of steady-state. Its hepatic metabolism is minimal and non-oxidative, making it safe for co-administration with inducers or inhibitors of liver enzymes. The major metabolite of the drug is a carboxylic acid derivative, which is inactive and represents about one-quarter of the administered dose. Levetiracetam is excreted by the kidneys and has an average half-life of 7 hours in adults. Renal impairment warrants therapeutic monitoring of serum drug concentration and dose adjustment.
The toxic effects associated with the use of levetiracetam include reduced hematocrit and erythrocyte count, decreased neutrophil count, drowsiness, weakness, and dizziness. These toxicities can also occur in drug concentrations in the blood within the therapeutic range.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.