Antibody screening for the Homer 3 antigen is indicated in cases of suspected autoimmune encephalitis and autoimmune cerebral ataxia.
Homer proteins are a family of proteins found in the postsynaptic membrane. The Homer 3 protein regulates the activity of the metabotropic glutamate receptors group I (mGluR1 and mGluR5).
The presence of autoantibodies against the Homer 3 antigen should be considered in the differential diagnosis of patients with subacute cerebral ataxia of unknown etiology.
See also: Anti-Neuronal Antibodies