The HHV-8 / KSHV IgG antibody test is a serological diagnostic tool used to detect antibodies against Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV). This virus is associated with several cancers, most notably Kaposi's sarcoma, and conditions such as primary effusion lymphoma and multicentric Castleman's disease, particularly in immunocompromised patients.
The HHV-8 / KSHV IgG antibody test is primarily used for:
- Epidemiological surveillance and research purposes to assess the prevalence of HHV-8 in specific populations.
- Screening organ transplant recipients or HIV-positive individuals to determine past exposure and potential risk of HHV-8-associated conditions.
Positive Result: Indicates past or current exposure to HHV-8. Further clinical assessment and monitoring may be required based on the patient's medical history and immune status.
Negative Result: Typically indicates no exposure to HHV-8. However, in cases of recent exposure, the test may be repeated to confirm seroconversion.
Understanding the serostatus of HHV-8 can help manage and mitigate the risk of developing related cancers and diseases, especially in patients with compromised immune systems.
The presence of antibodies indicates exposure to HHV-8 but does not distinguish between latent and active infections. Clinical correlation with patient symptoms and other diagnostic markers is essential for comprehensive management.
