Hepatitis C virus genotype determination is used to determine antiviral treatment in patients with chronic hepatitis C as well as to predict the course of the disease.
Unique nucleotide sequences of certain regions of the hepatitis C virus (HCV) genome allow it to be classified into 6 major genotypes. The geographical distribution, the outcome of the disease, and the response to antiviral therapy differ among the 6 genotypes. It is therefore very important to determine the genotype of the hepatitis C virus in order to make the best possible choice of antiviral treatment and optimize patient management.
Infection with HCV genotypes 2 and 3 have better therapeutic response rates (80-90%) than genotypes 1 and 4 (40-50%) in combination therapy with ribavirin and interferon. The duration of this treatment regimen ranges from 24 weeks for chronic hepatitis with HCV genotype 2 and 3, to at least 48 weeks for patients with HCV genotype 1 and 4.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
