Detection of hemosiderin (hemosiderinuria) is used in the investigation of hemolysis, as occurs in incompatible blood transfusions, in severe acute hemolytic anemia, or in hemochromatosis.
When the plasma free-hemoglobin levels are from 50 to 200 mg / dL after hemolysis, the ability of haptoglobin to bind free hemoglobin reaches its limits, and free hemoglobin passes easily through the kidneys. Part of the hemoglobin is absorbed by the cells of the proximal renal tubules, where the hemoglobin iron is converted to hemosiderin. When these cells subsequently drop into the urine, hemosiderinuria emerges. If hemoglobin cannot be absorbed by the cells of the proximal renal tubules, hemoglobinuria results.
This test includes a microscopic examination of the urine precipitate for the characteristic large blue hemosiderin granules when potassium ferrocyanide is added to the sample.
Hemosiderin (iron storage granules) is found normally in the liver, spleen, and bone marrow.
What Do Pathological Values Mean?
- Increase: Burns, presence of cold agglutinins, hemochromatosis, hemolytic anemia, haemosiderosis, megaloblastic anemia, paroxysmal nocturnal hemoglobinuria, pernicious anemia, renal tubular destruction, sickle cell anemia, thalassemia, multiple transfusions.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
