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Endometriosis, Genetic Testing

Includes 14 tests
Saliva
4 - 5 Weeks
210€

Endometriosis is a chronic condition in which tissue similar to the lining of the uterus grows outside the uterus. This can cause pain, inflammation, and adhesion formation. Management includes painkillers, hormone therapy, and, in some cases, surgery to remove abnormal tissue. The assessment of the Polygenic Risk Score for endometriosis is based on the examination of 13 gene polymorphisms.

Genetic testing for endometriosis is included along with 13 other diseases in the Genetic Screening for Endocrine and Genitourinary Diseases, Polygenic Risk Score.

Causes and non-genetic risk factors

It is a gynecological disorder characterized by endometrial tissue beyond the uterus, most often in the ovaries, fallopian tubes, and tissue lining the pelvis and more rarely beyond the pelvic organs. It is estimated that it occurs in 10% of women of reproductive age and leads to fertility problems, although there are effective treatments. There are several theories for the origin of endometriosis. Some suggest that fragments of the endometrium itself that are expelled during menstruation travel from the fallopian tubes to the ovaries and eventually enter the abdominal cavity. It has also been hypothesized that endometrial cells may travel through the bloodstream or lymphatic vessels to another location or that cells outside the uterus may turn into endometrial cells. In addition, a change in the immune system has been proposed in which the immune system cannot destroy ectopic tissue deposited outside the uterus. However, the exact cause of endometriosis remains unclear.

In addition, in addition to the hereditary-familial element described for endometriosis, other factors increase the risk of developing this condition, such as the following:

  • No previous birth
  • The onset of menstruation at an early age or menopause at an advanced age, which implies greater exposure to estrogen
  • Irregular menstrual cycles, either short (less than 27 days) or heavy menstrual cycles of more than seven days
  • Low body mass index
  • Disorders of the reproductive system or structural abnormalities of the uterus
Symptoms

Since it is an endometrial tissue, it follows the same cycle as the corresponding tissue found in the uterus with menstruation in response to hormones so that it may bleed. Still, it will be confined to the pelvic space, causing pain and inflammation. It is a pain similar to that of menstrual periods but of greater intensity that can also increase over time. The intensity of symptoms of endometriosis does not depend on the amount of endometrial tissue outside its usual location. Symptoms are very varied among women, but the most common include:

  • Painful periods (dysmenorrhea). The pain and cramps may start before and continue for several days after your period. It can extend to the lower back and abdomen.
  • Irregular menstruation.
  • Pain during or after sexual intercourse.
  • Pain during bowel movements or urination, most likely during menstruation.
  • Excessive bleeding, including intermenstrual bleeding.

Other symptoms that may accompany endometriosis, especially during periods, will depend on the location of the endometrial tissue, i.e., swelling of the abdomen, diarrhea or constipation, rectal bleeding (colon involvement), frequent and urgent need to urinate, bloody urine (bladder blockage). Because estrogen-dependent, symptoms improve after menopause and during pregnancy.

Prevention

Establishing guidelines for preventing endometriosis is impossible as its cause is unknown. It is a common disease that most likely begins to develop with the onset of menstruation, although it is not diagnosed until the age of 25-35 in general. However, it is possible to reduce estrogen exposure as much as possible by following a healthy diet based on foods rich in fiber, iron, and omega-3 fatty acids, avoiding alcohol and caffeinated beverages, leading an active life, and exercising regularly.

Additional information
Tests includedIncludes 14 tests
Sample Saliva
Results Time4 - 5 Weeks
Procedure completion test
Step 1

Purchase the test you want online

Select the tests you wish, through the most complete range of Preventive and Functional Medicine tests and purchase them online.

Step 2

Sampling

We send you the certified package - sampling collection kit, to collect your sample, always in accordance with the instructions contained within the kit.

Step 3

Sending your sample

After you have collected your sample, place it in the prepaid shipping package, contact the courier company and send it to our certified laboratory.

Step 4

Receiving the test results

Download your test results easily and securely anytime you want by logging in to your personal account.

Step 1

Book an appointment and buy the test online

Select from the most complete range test of Prevention, Andrology and Diagnostics, book an appointment in real time and purchase them online.

Step 2

Sampling

Visit the certified laboratory of Diagnostiki Athinon on the date and time you have chosen, to perform the sampling.

Step 3

Receiving the test results

Download your test results easily and securely anytime you want by logging in to your personal account.

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