URL path: Index page // Delta-Aminolevulenic Acid, Urine 24h

Delta-Aminolevulenic Acid, Urine 24h

Includes 1 test
Urine
10 Days
70€

The determination of delta-aminolevulinic acid in the urine is used for the laboratory diagnosis and differential diagnosis of porphyria, a group of diseases with signs and symptoms affecting the skin and nervous system. It can also be used in laboratory testing of lead poisoning in children.

Delta-aminolevulinic acid (ALA) is the precursor for porphobilinogen (PBG), a substance used in hemoglobin heme formation. The following steps in the biochemical pathway of heme synthesis are Porphobilinogen → Urobilinogen III → Uroporphyrin III → Porphobilinogen III → Coproporphyrin III→ Protoporphyrinogen → Protoporphyrin. This process then leads to the formation of heme. If any problem arises in the biochemical pathway of heme formation, delta-aminolevulinic acid accumulates and is excreted in the urine. Delta-aminolevulinic acid is not usually present in urine.

Delta-aminolevulinic acid concentrations in urine are significantly increased in many patients with acute neurological forms of porphyria. Screening for delta-aminolevulinic acid may be required in patients with symptoms that indicate acute porphyria, such as abdominal pain, nausea, constipation, peripheral neuropathy, muscle weakness, urinary retention, confusion, and hallucinations.

The presence of delta-aminolevulinic acid in the urine may additionally indicate lead poisoning. The test can be used as a pre-screening test to detect excessive lead absorption well before symptoms occur, especially in children.

Possible Interpretations of Pathological Values
 
  • Increase: Acute porphyria, alcohol abuse, hepatitis, liver cancer, lead exposure, lead poisoning. Medications: barbiturates, griseofulvin, penicillin, rifampicin.

See also:

Additional information
Tests includedIncludes 1 test
Sample Urine
Procedure completion test
Step 1

Book an appointment and buy the test online

Select from the most complete range test of Prevention, Andrology and Diagnostics, book an appointment in real time and purchase them online.

Step 2

Sampling

Visit the certified laboratory of Diagnostiki Athinon on the date and time you have chosen, to perform the sampling.

Step 3

Receiving the test results

Download your test results easily and securely anytime you want by logging in to your personal account.

Share it