Serum ceruloplasmin measurement is mainly used to diagnose Wilson's disease.
More information
Ceruloplasmin belongs to the alpha2-globulins and is a protein that transports copper (Cu). It also regulates the uptake of iron by transferrin. The ceruloplasmin test provides direct information about the amount of copper in the blood serum. The ceruloplasmin measurement is used to diagnose Wilson's disease, an inherited syndrome in which the levels of ceruloplasmin synthesized by the liver are reduced. Without ceruloplasmin to transport it, copper accumulates in the brain, eyes, kidneys, and liver tissues. One of the characteristics of this disease is the presence of copper deposits around the iris of the eye, known as Kayser-Fleischer rings.
The concentration of ceruloplasmin, an acute-phase protein, increases during stress, infections, neoplasms, and pregnancy.
Possible Interpretations of Pathological Values
- Increase: Cancer, cirrhosis, infection, rheumatoid arthritis, pregnancy, primary sclerosing cholangitis, stress, thyroid toxicity. Medications: Estrogens, methadone, oral contraceptives, phenytoin
- Decrease: Copper deficiency due to parenteral nutrition, Kwashiorkor, malabsorption, Menkes syndrome, nephrotic syndrome, normal infants (under 6 months), celiac disease, Wilson's disease
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
