The Antiphospholipid Antibodies, IgM Class, Immunodot test detects IgM autoantibodies against various phospholipids and protein cofactors, which are associated with Antiphospholipid Syndrome (APS) and an increased risk of thrombosis.
What Does This Test Detect?
This test identifies IgM antibodies against the following antigens:
- Cardiolipin (aCL). Often linked to arterial and venous thrombosis as well as recurrent miscarriages.
- Phosphatidic Acid
- Phosphatidylethanolamine
- Phosphatidylglycerol
- Phosphatidylinositol
- Phosphatidylserine
- Annexin V. Reduced Annexin V binding may increase the risk of clot formation.
- Beta-2-Glycoprotein I (β2GPI). A key antigen in APS, crucial for diagnosing the syndrome.
- Prothrombin (Factor II). Antibodies against prothrombin can interfere with coagulation, increasing the risk of thrombosis.
Clinical Significance
- The presence of these antibodies may indicate Antiphospholipid Syndrome (APS), which is characterized by arterial and venous thrombosis, recurrent pregnancy loss, thrombocytopenia, and other autoimmune complications.
- Frequently found in patients with Systemic Lupus Erythematosus (SLE) and other autoimmune disorders.
- Anti-prothrombin antibodies may contribute to an increased risk of thrombosis by interfering with coagulation.
- Helps diagnose and monitor individuals with suspected thrombophilia or autoimmune-related conditions.
Confirmation of Positive Results
Every positive result must be confirmed using the ELISA method, as per international guidelines, to avoid false positives and ensure an accurate diagnosis of Antiphospholipid Syndrome.
Why Choose This Test?
- High specificity and sensitivity.
- Provides a comprehensive diagnosis by detecting antibodies against multiple phospholipid antigens.
- Ideal for evaluating patients with unexplained thrombosis or recurrent pregnancy loss.
