Angiotensin I is a ten amino acid peptide formed by the breakdown of angiotensinogen by renin. Angiotensin I has little biological activity except that its high concentrations can stimulate catecholamine production. It is metabolized to biologically active angiotensin II by the Angiotensin Converting Enzyme (ACE). The formation of angiotensin I is controlled by the negative feedback of angiotensin I and II onto renin secretion and the concentration of aldosterone. Angiotensin I levels are elevated in many types of hypertension. Angiotensin I measurement is used to determine renin activity. Angiotensin I is excreted directly in the urine.
Medications such as diuretics, mineralocorticoids, glucocorticoids, estrogens, oral contraceptives, adrenocorticotropic hormone, sodium, and potassium as well as posture during blood sampling affect angiotensin I levels.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
