Serum angiotensin-converting enzyme measurement is used to investigate patients with possible sarcoidosis.
More information
Angiotensin-converting enzyme (ACE) is an enzyme found mainly in lung epithelial cells and at lower concentrations in blood vessels and kidneys. This enzyme is responsible for converting angiotensin I to angiotensin II, a vasoconstrictor, which stimulates the adrenal cortex to produce aldosterone. Elevated levels of angiotensin-converting enzyme have been found in patients with active sarcoidosis, which is believed to be produced by epithelial cells and macrophages of the granuloma. Thus, the angiotensin-converting enzyme assay is used to diagnose sarcoidosis and monitor the patient's response to treatment for the disease. It can also be used to diagnose Gaucher disease.
Possible Interpretations of Pathological Values
- Increase: Diabetes mellitus, Gaucher disease, hyperthyroidism, leprosy, liver disease, sarcoidosis
- Decrease: Medications such as ACE inhibitors, prednisone
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
