Α2-macroglobulin is one of the largest plasma proteins in size. It transports hormones and enzymes, has regulatory and inhibitory functions during the development of the lymphatic system, and inhibits components of the complement system and hemostatic mechanisms.
Elevated levels of alpha 2-macroglobulin are found in nephrotic syndrome when other low molecular weight proteins are lost, and A2-macroglobulin remains because of its large size. In patients with cirrhosis and diabetes, A2-macroglobulin levels are also elevated.
Patients with acute pancreatitis show low levels of A2-macroglobulin in the serum, and the extent of its decrease is related to the severity of the disease. Following serious surgeries, sepsis, and severe hepatic failure, A2-macroglobulin levels are often low. Patients with acute myocardial infarction and low A2-macroglobulin levels have a better prognosis.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
