Serum acid phosphatase measurement is used to predict relapse after radical prostatectomy for localized prostate cancer in combination with measurement of prostate-specific antigen.
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Acid phosphatase (ACP), an enzyme found mainly in the prostate gland, with high concentrations in the sperm. It is found at lower concentrations in the kidneys, liver, spleen, bone marrow, erythrocytes, and platelets. Acid phosphatase is used in the diagnosis of advanced metastatic prostate cancer and in monitoring the patient's response to treatment for prostate cancer.
In the past, acid phosphatase was used as a cancer marker for prostate cancer. However, following the discovery of prostate-specific antigen (PSA), monitoring of acid phosphatase decreased in popularity. Acid phosphatase is also used to examine vaginal secretions during rape investigations.
Possible Interpretations of Pathological Values
- Increase: Acute renal failure, bone metastases, breast cancer, cirrhosis, eclampsia, Gaucher disease, hemolytic anemia, hepatitis, hyperparathyroidism, liver tumors, multiple myeloma, obstructive jaundice. Medications: Anabolic steroids, androgens, clofibrate.
- Decrease: - Medications: Alcohol, fluorine, oxalates, phosphates.
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
