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Paracetamol (Acetaminophen), Serum

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Serum paracetamol is used to assess any drug toxicity in cases of overdose.

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Paracetamol or otherwise acetaminophen (Depon) is used as a painkiller and anti-fever medication without significant anti-inflammatory effects, which can become hepatotoxic when taken at concentrations greater than 150 mg / kg.

It is metabolized by the liver with a normal half-life of less than 4 hours. At overdose, liver glutathione is consumed, and the toxic metabolite produced reacts with the cellular proteins resulting in hepatotoxicity, potentially lethal if left untreated. N-acetylcysteine ​​can substitute for glutathione and serves as an antidote.

Serum paracetamol concentration and knowledge of half-life is the only way to assess early-onset poisoning, as other liver function tests (bilirubin, transaminases) do not show clinically significant increases until they develop in the liver.




Important Note

Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.

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