Urine oxalate determination is used to monitor treatment for kidney stones, to assess the risk of kidney stones due to oxalate, and to diagnose primary and secondary peroxaluria.
Oxalate is an end product of urinary metabolism. Oxalic acid can be combined with calcium to form calcium oxalate. Oxalates can accumulate in kidney and bladder tissues and cause kidney stones, chronic inflammation and fibrosis.
Increased urinary oxalate excretion may be the result of hereditary deficiencies (primary peroxaluria), gastrointestinal disorders associated with poor absorption of fat (secondary peroxaluria), or due to increased intake of rich oxalicin or C rich foods.
Possible Interpretations of Pathological Values
- Increase: Celiac disease, cirrhosis, Crohn's disease, ethylene glycol poisoning, diabetes mellitus, poor fat absorption (severe), peroxaluria (primary), nephrolithiasis, pancreatic insufficiency, sarcoidosis, Vitamin B6 deficiency. Medications: Large doses of ascorbic acid and calcium.
- Decrease: Gastrointestinal disease or surgery that affects absorption. Hyperglycaemia, renal failure.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.