17-hydroxyprogesterone is a hormone found to be elevated in patients with congenital adrenal hyperplasia. The measurement of 17-hydroxyprogesterone is also used to investigate hirsutism and infertility in women as well as to confirm or exclude certain adrenal and ovarian tumors.
17-hydroxyprogesterone (17-OHP), which is derived from progesterone, is the precursor metabolite of 11-deoxycortisol in the biosynthetic pathway of cortisol. Increased levels generally occur as a result of the lack of enzymes 21-hydroxylase or 11-hydroxylase. 17-hydroxyprogesterone is converted and eliminated as pregnanetriol.
Possible Interpretations of Pathological Values
- Increase: Antley-Bixler syndrome, congenital adrenal hyperplasia, spermatocytic seminoma, hirsutism, ovarian cysts, ovarian tumors, polycystic ovary syndrome (PCOS), masculinization. Medications: steroids in premature infants, metformin.
- Decrease: No clinical significance.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.