Selenium (Se) is a key trace element, necessary for the completion of many normal functions. As a component of enzymes such as glutathione peroxidase and selenoproteins, it plays a crucial role in many biological processes, including antioxidant defense, fertility in both men and women, thyroid metabolism, immune function, carcinogenesis, endocrine function, in the occurrence of cardiovascular disease and in the development and function of muscles. A small deviation of the Selenium concentration from normal levels can have serious consequences.
Selenium is a key element for normal testicular development, spermatogenesis, spermatozoa motility, and function. The testes contain high concentrations of Selenium and small deviations, either lack or excessive accumulation, can lead to abnormal growth.
Decreased semen selenium levels have been found in patients:
- With elevated levels of MDA (Malondialdehyde) - an indicator of lipid peroxidation
- With increased rates of sperm DNA fragmentation
- With reduced motility and concentration of spermatozoa as well as with increased pathological forms
- In patients with varicocele