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Secretory Immunoglobulin A (sIgA), Saliva

Includes 1 test
Saliva
3 Days
50€

Secretory immunoglobulin A (sIgA) is a subclass of immunoglobulin A (IgA), an antibody that plays a critical role in mucosal immunity. Secretory immunoglobulin A is the major immunoglobulin found in the mucous secretions of the lacrimal glands, salivary glands, mammary glands, respiratory system, urogenital system, and gastrointestinal tract. Secretory immunoglobulin A is not synthesized by the epithelial cells of the mucous membranes of the aforementioned tissues and organs and is not derived from blood. Secretory immunoglobulin A is produced by B lymphocytes located near mucosal cells and then transported and released by specific cellular mechanisms of epithelial cells to extracellular secretions. Secretory IgA plays a key role in protecting vulnerable areas such as the oral cavity, lungs, and intestine from invasion by pathogens.

The secretion of sIgA shows a daily (circadian) rhythm, with the highest levels observed in the morning and the lowest in the evening. The levels of secreted immunoglobulin A in saliva vary depending on the physical and psychological stress through interactions with the autonomic nervous system. Salivary sIgA levels are affected by salivary flow rate, with its concentrations decreasing as the flow rate increases.

Why is it important to test the secretory Immunoglobulin A in saliva?

The usefulness of testing secretory IgA in saliva lies in assessing the function of the immune system both locally in the oral cavity and in the entire immune system. Elevated sIgA levels may indicate a strong immune response to an antigen or pathogen, while decreased sIgA levels are indicative of reduced mucosal immunity.

Saliva sIgA measurement is used to monitor athletes during periods of intense preparation to assess their susceptibility to infections or to investigate children with frequent upper respiratory tract infections or even as an indicator of environmental stress. Salivary IgA secretion levels have also been linked to the presence of tooth decay.

Decreased salivary IgA secretion is a common finding in patients with multiple sclerosis.

Additional information
Tests includedIncludes 1 test
Sample Saliva
Procedure completion test
Step 1

Purchase the test you want online

Select the tests you wish, through the most complete range of Preventive and Functional Medicine tests and purchase them online.

Step 2

Sampling

We send you the certified package - sampling collection kit, to collect your sample, always in accordance with the instructions contained within the kit.

Step 3

Sending your sample

After you have collected your sample, place it in the prepaid shipping package, contact the courier company and send it to our certified laboratory.

Step 4

Receiving the test results

Download your test results easily and securely anytime you want by logging in to your personal account.

Step 1

Book an appointment and buy the test online

Select from the most complete range test of Prevention, Andrology and Diagnostics, book an appointment in real time and purchase them online.

Step 2

Sampling

Visit the certified laboratory of Diagnostiki Athinon on the date and time you have chosen, to perform the sampling.

Step 3

Receiving the test results

Download your test results easily and securely anytime you want by logging in to your personal account.

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