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Transferrin, Serum

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Serum transferrin is used to control chronic iron overload conditions such as hereditary hemochromatosis.

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Transferrin, or otherwise, siderophyllin, belongs to the beta globulins and is a glycoprotein with a relatively short (about 7 days) half-life. It is formed in the liver and transports iron from the intestinal mucosa to iron storage sites and hemoglobin synthesis sites (bone, muscle, erythrocytes, lymphocytes). Transferrin allows the transfer of iron by binding to the transferrin receptors.

Transferrin is capable of binding more than its weight to iron (1 g of transferrin can carry 1.43 g of iron). Normally, iron saturation (transferrin saturation) is between 20% and 45%. Due to the short half-life, its values ​​decrease more rapidly in malnutrition than albumin.

Possible Interpretations of Pathological Values
  • Increase: Iron deficiency anemia with normal protein levels, pregnancy. Medications: Carbamazepine, estrogen, oral contraceptives
  • Decrease: Congenital absence of transferrin (hereditary atansferrinemia), haemolytic anemia, hepatic disease (acquired), inflammation (chronic), iron overload, low iron in combination with malnutrition, neoplasia, neovirostasis, proteinuria. Medications: Cortisone



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