The serological test for Rickettsia conorii is used for the laboratory diagnosis and monitoring of patients with medullary fever.
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The species of the genus Rickettsia are Gram-negative, strictly intracellular bacilli that multiply within the endothelial cell cytoplasm. Rickettsia conorii, is the causative agent of Mediterranean spotted fever. Ticks are both the carrier and the main reservoir of spotted Mediterranean fever. People are usually infected through a tick bite or less often by the infected tick's blood after it is crushed.
In general, the disease is clinically characterized by a combination of fever, headache, myalgia and a dermal blotch rash affecting the whole body including the palms and soles. Grass may develop in place of the sting from the tick, but it often remains unnoticed, and there is also local lymphadenopathy. The incubation period is usually 4 to 7 days. Mediterranean spotting fever is generally considered a benign progressive disease, but serious complications are reported in 6% of patients. Malignant forms of the disease can cause rash, and can lead to neurological, kidney, or heart complications.
The diagnosis of rickets is based on serological tests. The presence of antibodies is usually detected 10 days after the onset of systemic symptoms and antibody titers peak after 3 to 4 weeks or even later if antibiotic therapy is given.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
