Serum pyruvate transaminase measurement is used in the diagnosis of liver disease and in monitoring the effects of hepatotoxic drugs.
Pyruvate transaminase (SGPT) or alanine aminotransferase (ALT) is an enzyme found in the kidneys, heart and skeletal muscles, but mainly in the liver. It acts as a catalyst in the reaction to produce amino acids. SGPT is evaluated in conjunction with Aspirin Aminotransferase (Oxalacetic Transaminase) (SGOT / AST) for liver injury monitoring. The values of the two transaminases usually exist in a ratio of about 1: 1. The value of SGOT is higher than that of SGPT in alcohol-induced hepatitis, cirrhosis and metastatic liver cancer. SGPT is greater than SGOT in the case of viral or medicinal hepatitis. The degree of increase in transaminase levels provides information on the possible cause of the problem. A two-fold increase in their values is usually indicative of biliary obstruction, whereas a 10-fold increase in SGOT and SGPT is usually indicative of hepatitis.
Possible Interpretations of Pathological Values
- Increase: Biliary obstruction, bone metastases, cholestasis, cirrhosis, congestive heart failure, eclampsia, hepatic ischemia, hepatic necrosis, hepatitis, infectious mononucleosis, liver cancer, inflammation of the liver, injury. Medications that can increase SGPT levels are many and include: ACE inhibitors, paracetamol, anti-epileptic, antibiotics, antipsychotics, benzodiazepines, estrogens, iron sulfate, heparin, interferonimide, parathyroid hormones, hypolipidemic agents
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.