This test is used to confirm or exclude the presence of lupus anticoagulant (LAC), with the aim of separating it from other specific and non-specific coagulation factor inhibitors in the laboratory. Lupus anticoagulant measurement is also used, along with other tests, in the investigation of prolonged activated thromboplastin time (APTT).
Lupus anticoagulant is an antibody to negatively charged phospholipids which interferes with phospholipid-dependent coagulation tests.
Lupus anticoagulant is usually found in patients with systemic lupus erythematosus, but not limited to them. Lupus anticoagulant is also associated with other autoimmune disorders, vasculitis and collagen diseases and may occur after taking certain medications or certain infections (eg respiratory tract infections in children) as well as in persons without obvious underlying disease.
Lupus anticoagulant has been associated with arterial and venous thrombosis, pulmonary embolism and miscarriage in pregnant women. Persons with thrombocytopenia or coagulation factor deficiency and presence of lupus anticoagulant may be at risk of bleeding.
What Do Pathological Rates Mean?
- Increase: Anti-phospholipidemic syndrome, systemic lupus erythematosus, thrombosis, thrombocytopenia, recurrent miscarriage, syphilis, acute infection, elderly. False-positive results have been observed in patients taking medications such as chlorpromazine, hydralazine, penicillin, phenytoin, procaineamide, quinidine
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.