The purpose of white blood cells is to protect the body from the threat of foreign agents, such as bacteria. All blood cells, including white blood cells, red blood cells, and platelets, come from a common stem cell. The differentiation of blood cells takes place in the bone marrow.
Phagocytic white blood cells, which include granulocytes and monocytes, play an important role in the process of phagocytosis and digestion of cell debris. The granulocytes were so named because of their granular appearance. These cells are also called polymorphonuclear because of their multilobular nuclei. The three types of granulocytes are neutrophils, eosinophils and basophils. Monocytes along with lymphocytes are considered mononuclear leukocytes (or non-granulocytes), since their nuclei are not multilobular.
Neutrophils are the first white blood cells to reach the site of inflammation. They begin their work by cleansing the area of cellular debris through the phagocytosis process. Neutrophils have a life span of around 4-5 days. Mature neutrophils are distinguished by the super-lobular appearance of their nuclei (hyper-segmented neutrophils), possessing from two to five lobes and which increase (turn to the right) during pathological conditions. Immature neutrophils do not have a lobular appearance of their nuclei, they are called rod nuclei neutrophils and increase their number (turn to the left) during conditions that increase white blood cell production.
Eosinophils play an important role in the defense against parasitic infections. They can also phagocytize cellular remnants, but to a lesser extent than neutrophils, and in the later stages of inflammation. They also play a role in allergic reactions.
Basophils release histamine, bradykinin and serotonin when triggered by injury or infection. These substances are important for the inflammatory process as they increase capillary permeability and thus increase blood flow to the affected area. Basophils are also involved in allergic reactions. In addition, the granules on the surface of the basophils secrete the natural anticoagulant, heparin.
Monocytes, which live for months or even years, are not considered phagocytic cells when they circulate in the blood. However, when they remain in tissues for several hours, the monocytes mature into macrophages, which are phagocytic cells.
Lymphocytes, including T lymphocytes (T cells) and B lymphocytes (B cells), mature in lymphoid tissue and migrate between blood and lymph. Lymphocytes have a life span of days or years, depending on their type.
The measurement of white blood cells and their type is included in the General Blood Test and includes two sections. 'White blood cell count' means the total and absolute number of white blood cells (leukocytes) and their types in 1 mm3 of blood. The other section comprises of basophils, eosinophils, lymphocytes, monocytes and neutrophils. Since the percentages are always equal to 100%, an increase in the percentage of one type of white blood cell causes a mandatory decrease in the percentage of at least one other type of white blood cell.
"Turn to the left" means that there is an increased number of immature neutrophils in peripheral blood. Neutrophils are usually depicted from left (young cells) to right (mature cells). A low number of left-leaning total white blood cells indicates a recovery following bone marrow suppression or an infection of such intensity that the demand for neutrophils in the tissues is greater than the ability of the bone marrow to release them into circulation. A high number of left-leaning total white blood cells indicates increased neutrophil release from the bone marrow in response to an infection or inflammation.
"Turn to the right" means that neutrophils have more nuclear lobes than normal. This happens in liver disease, Down syndrome, in megoblastic and pernicious anemia.
Causes of White Blood Cells Increase
Abscess, actinomycosis, amputation, Andersen's disease, anemia (acquired, haemolytic), anorexia, anoxia, carbon, appendicitis, bacterial infections, blastomycosis, bronchitis, burns, chickenpox, acute cholecystitis, cholelithiasis, cholera, cirrhosis (with necrosis), colon cancer, epileptic seizures, Crohn's disease, laryngitis, Cushing's syndrome, cytomegalovirus infection, dengue fever, diphtheria, rupture of aortic aneurysm, ectopathitis, ectoplasmosis, dysproteinemia, dysproteinemia strain, endocarditis, Epstein-Barr virus infection, embryonic erythroblastosis, exercise, ultraviolet radiation, fatty liver, fever of unknown origin, G6PD deficiency, gangrene, glomerulonephritis (metastreptococcal), gout (acute), heart transplant rejection, bleeding, hepatitis (alcoholic), hepatoma, hookworm, Hodgkin's disease, idiopathic myelofibrosis, infection (bacterial, parasitic), infectious mononucleosis, intestinal obstruction, ketoacidosis, lactic acidosis, Legionnaires' disease, leukemia, leukocytosis, lymphoma, meningitis, menstruation, myocardial infarction, myocarditis, pancreatitis, peritonitis, pneumonia, poisoning (arthropods, chemicals, minerals, other poisons), true multicellularemia, post-operative stress, smallpox, stress, pulmonary cholangitis, systemic lupus erythematosus, tonsillitis, toxic shock syndrome, transfusion reaction, trauma, tuberculosis, tularemia, tumor necrosis, ulcers, ultraviolet radiation, UV radiation number, Wegener granulomatosis, Weil's disease. Medications: Allopurinol, anesthetics, atropine sulfate, barbiturates, diethylcarbamazine, epinephrine, erythromycin, steroids, streptomycin sulfate, sulfonamides. Herbs or natural remedies that increase Stimulating Factor (GCSF) as well as those that increase lymphocytes include Viscum album and Echinacea purpurea.
Causes of Neutrophils Increase
Acute infections, allergies, anemia, anoxia, stress, appendicitis, asthma, burns, cancer, chickenpox, cholecystitis, cholera, colitis, dermatitis, Cushing's syndrome, diabetic acidosis, diphtheria, fear, G6PD deficiency, gangrene, gout, hemorrhage, inflammation, ketoacidosis, pregnancy and childbirth, leukemia, leukocytosis, lymphoma, meningitis (pyogenic), myocardial infarction, osteocardiosis, osteomyelitis ritonitida, pernicious anemia, pneumonia, poisoning (carbon monoxide, lead, mercury, arsenic, turpentine), polycythemia vera, postoperative stress, pulmonary infarction, pyelonephritis, rheumatic fever, rheumatoid arthritis, salpingitis, scarlet fever, sepsis, smallpox, smoking, thyroiditis, tonsillitis, transfusion reaction, typhoid, ureaemia. Medications: Acetylcholine, benzene, carbon monoxide, casein, chloropropamide, corticosteroids, corticotropin, ringworm, epinephrine, ethylene glycol, histamine, heparin, insect poisoning, lithium chloride, lead
Causes of Eosinophilic Increase
Addison's disease, allergies, kidney disease, asthma, brucellosis, cancer (bone, brain, ovarian, testicular), chorea, coccidioidomycosis, dermatitis, diverticulitis, ectochemical, leukemia, eczema, lupus, leukocytosis, Löffler syndrome, malaria, metastatic carcinoma, parasitic infections, pemphigus, pernicious anemia, phlebitis, true polycythemia, psoriasis, jaundice-induced pruritus, radiotherapy, rheumatoid arthritis, cellular anemia, splenectomy, thrombophlebitis, tuberculosis, ulcerative colitis, Sjogren's syndrome. Medications: Antibiotics (associated with allergic reactions), allopurinol, aminosalicylic acid, antispasmodics, cephalosporins, chlorpropamide, digoxin, heparin, imipramine, methotrexate, nitrofurantoin, penicillin, phenothiazine, procainamide, procarbazine, propranolol, quinidine, streptomycin, sulphonamides, tetracycline.
Causes of Basophil Increase
Allergic reaction to food / medicine / inhaled substances, chicken pox, chronic myelogenous leukemia, erythroderma, Heinz body anemia, Hodgkin's disease, hypothyroidism, radiation, leukocytosis, myelofibrosis, myxedema, nephrotic syndrome, periarthritis, polycythemia, seronosis, sinusitis, smallpox, splenectomy, ulcerative colitis, urticaria. Medications: Antithyroid, desipramine, estrogen.
Causes of Lymphocyte Increase
Brucellosis, cytomegalovirus infection, diverticulitis, diverticulosis, endocarditis, hepatitis, Hurler syndrome, infectious mononucleosis, leukocytosis, lymphocytic leukemia, pertussis, syphilis. Medications: Aspirin, haloperidol, lead poisoning, levodopa, phenytoin, tetrahydrochloride poisoning.
Causes of Monocyte Increase
Brucellosis, carbohydrate poisoning, Epstein-Barr virus infection, Hodgkin's disease, leukemia (AML, CML), leukocytosis, multiple myeloma, rheumatoid arthritis, salmonellosis, sarcomelidosis, sarcoidosis, syphilis Medications: Haloperidol, methoxuximide.
Causes of White Blood Cell Decrease
Atherosclerosis, Acquired Immunodeficiency Syndrome (AIDS), alcoholism, anaphylactic shock, anemia (aplastic, malignant), amyloidosis, anorexia nervosa, carbonosis, arsenic poisoning, brucellosis, Felty syndrome, Gaucher disease, heavy chain disease, hepatitis (infectious, viral), hyperplasia, hypothermia, idiopathic myelofibrosis, Hodgkin's disease, infection (severe bacterial, viral), flu, Legionnaires' disease, leishmaniasis, leukemia (some forms), leukopenia, lymphoma, measles, mononucleosis, myxoid edema, paratyphoid, pharyngitis, pneumocystis pneumonia, proleukemia, proteinuria, psittacosis, Q fever, radiation therapy, renal syndrome, renal trauma, stomatitis, strogyloidosis, toxoplasmosis, tuberculosis, tularemia, typhoid fever. Medications: Acetaminophen, aminoglutethimide, aminopyrine, antibiotics, antineoplastics, anti-thyroid, arsenic, aurothioglucose, bismuth, chloramphenicol, chloroquine phosphate, diazepam, diethylcarbamazine, ethotoin, frusemide, immunosuppressants, meprobamate, methyldopa, methsuximide, phenothiazines, phenylbutazone, phenytoin, primidone, hydrochloride procaineamide, quinacrine hydrochloride, quinine sulfate, sulfonamides, vitamin A.
Causes of Neutrophil Decrease
Acromegaly, Addison's disease, atherosclerosis, anaphylactic shock, nervous anorexia, aplastic anemia, brucellosis, cachexia, carcinoma, Chediak-Higashi syndrome, chemotherapy, cirrhosis, dengue fever, Felty syndrome, folic acid deficiency, Gaucher disease, hypersplenism, pituitary dysfunction, hypothyroidism, infections, infectious hepatitis, infectious mononucleosis, influenza, iron deficiency anemia, Kala-azar, malaria, measles, mumps, myelofibrosis, myeloma, paratyphoid, paroxysmal anemia, paroxysmal anemia thrust, radiotherapy, Rocky Mountain Fever, rubella, measles, sarcoma, sepsis, thyrotoxicosis, tularemia, typhoid fever, vitamin B12 deficiency, yellow fever. Medications: Alcohol, aminophylline, antipyrine, aminopyrine, ampicillin, male, aspirin, barbiturates, carbimazole, cephalothin, chemotherapeutic agents, chloramphenicol, chlorpromazine, chlorpropamide, diazepam, dinitrophenol, diuretics, electroconvulsive, gold salts, imipramine, indomethacin, isoniazid, mephenytoin, 6-mercaptopurine, methicillin, p-aminobenzoic acid, penicillin, phenacetin, phenylbutazone, phenylhydrazine, phenytoin, procaineamide, quinine, streptomycin, sulfonamide, sulfonamide ipelenamine, urethane.
Causes of Eosinophil Decrease
Acromegaly, anemia (aplastic), coccidiosis, congestive heart failure, Cushing's syndrome, systemic lupus erythematosus, eclampsia, Goodpasture's syndrome, hyperplasia, infections, infectious mucus Medications: Adrenocorticotropic hormone, corticotropin, epinephrine, glucocorticoids, methysergide, niacin, niacinamide, procainamide, thyroxine.
Causes of Basophil Decrease
Acute infection, anaphylaxis, Cushing's syndrome, hyperthyroidism, ovulation, pregnancy, radiation therapy, thyroid toxicity, stress. Medications: Chemotherapeutics, corticosteroids, corticotropin, procainamide, thiotepa.
Causes of Lymphocyte Decrease
Aplastic anemia, Cushing's syndrome, Hodgkin's disease, immunoglobulin deficiencies, leukemia (chronic granulocytic, monocytic), lymphosarcoma, renal failure, systemic lupus erythematosus, thymic hypoplasia in children. Medications: asparaginase, chlorambucil, cortisone, epinephrine, glucocorticoids, lithium compounds, mechlorethamine, niacin, lymphoid tissue radiotherapy.
Causes of Monocyte Decrease
Aplastic anemia, hairy cell leukemia
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.