Serum hydroxybutyrate dehydrogenase measurement is used in the diagnosis of myocardial infarction.
Hydroxybutyrate dehydrogenase (HBDH) is an enzyme similar to lactate dehydrogenase 1 (LDH1), which is found in the brain, heart muscle, kidneys and red blood cells. It is generally used to diagnose myocardial infarction, although its levels may also be elevated when there is damage to other organs. Measurement of HBDH levels is more specific and takes longer than creatine kinase (CPK), oxalacetic transaminase (SGOT / AST) and total lactate dehydrogenase (LDH) measurement to diagnose myocardial infarction. Hydroxybutyrate dehydrogenase levels increase within 8-10 hours after the onset of infarction, peak at 48-96 hours after, and remain abnormal for 16-18 days.
Possible Interpretations of Pathological Values
- Increase: Anemia (hemolytic or megaloblastic), carbon monoxide poisoning, hepatocellular damage, leukemia, lymphoma, malignant melanoma, muscular dystrophy, myocardial infarction, nephrodromic syndrome, nephrotic syndrome.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
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