The measurement of urobanilic acid in the urine is used to monitor patients with catecholamine-secreting tumors, to monitor the treatment of patients with neuroblastoma, and to control patients with potential congenital catecholamine metabolism disorders.
Homobanilic acid (HVA) is the major end-metabolite of dopamine, one of the three catecholamines. Dopamine breaks down in the liver and is excreted in the urine as homobanilic acid. Elevated levels may occur as a result of catecholamine-secreting tumors. In general, homobanilic acid as well as other catecholamine metabolites such as vanilylamandelic acid (VMA) are typically elevated in patients with catecholamine-secreting tumors (e.g., neuroblastoma and pheochromocytoma).
Possible Interpretations of Pathological Values
- Increase: Brain tumors, Costello syndrome, ganglion neuroblastoma, occupational exposure to manganese, neuroblastoma, pheochromocytoma. Medications: Aminosalicylic acid, disulfiram, levodopa, methocarbamol, reserpine
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
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