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Glycoprotein ΙΙΙa (GPIIIa), HPA-1 Polymorphism

Includes 1 test

Molecular screening for HPA-1a / b polymorphism of the glycoprotein IIIa gene (GPIIIa HPA-1a / HPA-1b) is performed to assess the risk of thrombosis in asymptomatic patients with a severe familial history or in patients who have already had a thrombotic episode.

Glycoprotein IIIa (GPIIIa or CD61 or integrin β3) together with glycoprotein IIIb (GpIIb or CD41) form a receptor on the surface of the platelets to which fibrinogen and von Willebrand factor bind and participate. Glycoprotein IIIa is encoded by the ITGB3 gene located on chromosome 17. The existence of HPA-1b polymorphism has been associated with cases of myocardial infarction at relatively young ages (<55 years) and with an increased risk of coronary artery thrombosis interventions using stents. The b allele in combination with the 4G allele of the PAI-1 gene, increases the chance of myocardial infarction. Heterozygotes for the b allele appear to be resistant to the action of antithrombotic drugs e.g. in aspirin.

Thrombophilia is an acquired or congenital disorder associated with thrombosis. The clinical appearance of an underlying thrombophilia mainly involves venous thromboembolism, which is manifested as deep vein thrombosis, pulmonary embolism, or superficial vein thrombosis. Other events associated with thrombophilia include prolonged (recurrent) miscarriages and complications of pregnancy such as severe preeclampsia, placental abruption, and fetal endometrial death. The demographic and environmental characteristics that contribute to the risk of venous thromboembolism in people predisposed to thrombophilia include: old age, gender (more commonly in men), obesity, surgery, trauma, hospitalization, etc. malignant neoplasms, prolonged immobility (such as long plane trips), use of certain medications (such as contraceptives, estrogens, tamoxifen and raloxifene) and certain drugs used to treat and equalize low blood glucose levels in hypoglycemia.



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