The measurement of glucose 6-phosphate dehydrogenase is used in the control of patients with hemolytic anemia and to check for possible enzyme deficiency.
Glucose 6-phosphate dehydrogenase (G6PD) is an enzyme normally present in erythrocytes. This enzyme is part of the biochemical pathway of pentose phosphate that metabolizes glucose and works to protect cells from damage caused by oxidizing agents. G6PD deficiency is a sex-linked genetic disorder that occurs predominantly in men and leads to hyperbilirubinemia, jaundice and red blood cell hemolysis, causing anemia after taking certain medications.
Medications and substances that can cause hemolytic episodes in subjects with deficiency of the enzyme are: acetanilide, aketylofainylydrazini, antipyrine, ascorbic acid, acetylsalicylic acid, chloramphenicol, nalidixic acid, naphthalene, nitrofurantoin, nitrofuran, pentaquine, phenacetin, phenylhydrazine, primakin probenecid, quinacrine, quinidine, quinine, sulfonamides, vitamin K.
Other conditions that can lead to haemolysis include diabetic acidosis, eating beans (cyanosis), infections (viral, bacterial) and septicemia.
Possible Interpretations of Pathological Values
- Increase: Anemia (malignant, megoblastic), hepatic coma, hyperthyroidism, leptospirosis, myocardial infarction, Werlhof's disease (idiopathic thrombocytopenic purpura).
- Decrease: Anemia (congenital haemolytic non-cellular), cystitis, congenital G6PD deficiency, neonatal hemolytic neonatal disease. Drugs: cefoperazone / sulbactam, gentamicin sulfate, ntimilicin sulfate, tocopherol.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.