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Extractable Nuclear Antigen Antibodies (Anti-ENA), Serum

Includes 1 test
Blood
15€

Screening for anti-ENA antibodies is used to investigate patients with connective tissue autoimmune symptoms and signs and in whom anti-nuclear antibodies (ANAs) are positive.

Antibodies against Extractable Nuclear Antigen (ENA) or anti-ENA are used to diagnose systemic lupus erythematosus (SLE) and mixed connective tissue disease and to exclude other autoimmune diseases. Anti-ENAs are a type of anti-nuclear antibody against certain core antigens consisting of RNA and proteins. The most common ENA antigens are Smith (SM) and ribonucleoprotein (RNP). The ENA antigens also include SSA / Ro, SSB / La, Jo-1 and Scl-70.

Nuclear Smith (anti-Smith, anti-SM) are found in about 30% of patients with systemic lupus erythematosus and in about 8% of patients with mixed connective tissue disease. However, they are not found in patients with other collagen diseases.

Nuclear antibodies against ribonucleoprotein (anti-RNP) are found in approximately 100% of patients with mixed connective tissue disease and in approximately 25% of patients with systemic lupus erythematosus, disc lupus and progressive systemic sclerosis (scleroderma). High anti-RNP titers indicate mixed connective tissue disease.

Antibodies against histidyl tRNA synthetase (Anti-Jo-1) are found in patients with autoimmune interstitial pulmonary fibrosis and in a few patients with autoimmune myositis.

Anti-SSA / Ro and anti-SSB / La antibodies are mainly used in the diagnostic evaluation of Sjögren's syndrome.

Scleroderma antibodies (anti-Scl-70) are found in patients with scleroderma and CREST syndrome.

 

 

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Additional information
Tests includedIncludes 1 test
Sample Blood
Procedure completion test
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