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Ehrlichia sp., Molecular Detection

Includes 1 test

Molecular testing for Ehrlichia is used to definitively diagnose and document Ehrlichia.

Cochlea and anaplasma are a group of tick-borne infectious zoonoses caused by the very related species Ehrlichia and Anaplasma, respectively. These micro-organisms have obligatory intracellular lives, are Gram negative, belong to the rickets group, infect leukocytes and cause a potentially serious inflammatory disease in humans.

Human monocytic coiling is caused by the species Ehrlichia chaffeensis, which is transmitted by the tick Amblyomma americanum and is epidemiologically predominant in US areas. Ehrlichia ewingii and Ehrlichia canis, the cause of the dog's granulocytic leukemia, can sometimes cause disease in humans. The clinical and laboratory findings are similar to those of E. chaffeensis infection.

Most cases of anaplastic and parenchymal disease are subclinical or mild, but the infection can become serious and life threatening in some patients, mainly immunosuppressed. Symptoms such as fever, fatigue, general malaise, headache and other "flu" symptoms, including myalgia, joints and nausea, are more common. The involvement of the central nervous system can lead to convulsions and coma.

Diagnosis of the disease can be difficult as the clinical course of the patient is often mild and without specific symptoms. Symptoms can easily be attributed to other diseases, such as influenza or other zoonoses such as Lyme disease, rocky-borne fever. Indications for the diagnosis of cochlear disease in a patient after known exposure to ticks include laboratory findings such as leukopenia, thrombocytopenia and elevated serum transaminases which, while frequently present, are not specific. Rarely, intracellular micro-organisms can be observed in peripheral blood smears, but this is not a reliable indicator for the diagnosis of human cochlear or anastomosis.

The definitive diagnosis of the disease is achieved by the molecular PCR method.



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