Double-stranded DNA antibody measurement is used in the evaluation of patients with signs and symptoms compatible with systemic lupus erythematosus (SLE) as well as in the monitoring of patients with documented SLE for outbreaks and recurrences of the disease.
This test detects the presence of antibodies against the double chain of DNA. The presence of anti-dsDNA (or simply anti-DNA) antibodies indicates that the patient is suffering from some form of autoimmune disease. The resulting antibody-antigen complexes play an important role in the tissue damage observed in autoimmune diseases. Anti-dsDNA antibodies are particularly common in patients with systemic lupus erythematosus (> 85% of patients). Determination of anti-DNA antibodies is useful in the diagnosis of systemic lupus erythematosus and in monitoring its course.
Possible Interpretations of Pathological Values
- Increase: Lupus nephritis, severe myasthenia, rheumatoid arthritis, scleroderma, Sjogren's syndrome, systemic lupus erythematosus. Medications: hydrazine, procainamide.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.