Serum angiotensin converting enzyme measurement is used to investigate patients with possible sarcoidosis.
Angiotensin converting enzyme (ACE) is an enzyme found mainly in lung epithelial cells and at lower concentrations in blood vessels and kidneys. This enzyme is responsible for the conversion of angiotensin I to angiotensin II, a vasoconstrictor, which in turn stimulates the adrenal cortex to produce aldosterone. Elevated levels of angiotensin converting enzyme have been found in patients with active sarcoidosis, which is believed to be produced by epithelial cells and macrophages of the granuloma. Thus, the angiotensin converting enzyme assay is used in the diagnosis of sarcoidosis as well as in monitoring the patient's response to treatment for the disease. It can also be used in the diagnosis of Gaucher disease.
Possible Interpretations of Pathological Values
- Increase: Diabetes mellitus, Gaucher disease, hyperthyroidism, leprosy, liver disease, sarcoidosis
- Decrease: Medications such as ACE inhibitors, prednisone
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.